Molecular Characteristics of Bovine Viral Diarrhea Virus Strains Isolated from Persistently Infected Cattle

In this study, we reported the isolation, identification, and molecular characteristics of nine BVDV strains that were isolated from serum persistently infected cattle. The new designated as TJ2101, TJ2102, TJ2103, TJ2104, TJ2105, TJ2106, TJ2107, TJ2108 TJ2109. TJ2102 TJ2104 found to be cytopathic BVDV, other non-cytopathic BVDV. An alignment phylogenetic analysis showed isolates share 92.2–96.3% homology with CP7 strain and, thus, classified BVDV-1b subgenotype. A recombination genome sequences could recombined by major parent BVDV-1a NADL minor BVDV-1m SD-15 strain. Some variations or unique amino acid mutations in 5′-UTR, E0 E2 these isolates. addition, a potential linear B cell epitopes prediction epitope at positions 56–61 is highly variable BVDV-1b. conclusion, present study has identified cattle China. Further studies on virulence pathogenesis are recommended.